… group family that regulates gene expression by inducing … , we hypothesized that LEF1
regulated the progression of … f RNF121 expression in LEF1-altered expressing chondrocytes was …

… SIRT1 directly represses LEF1 gene expression by binding its … costal and articular chondrocytes
from ATC Lef1 fl/fl and Lef1 fl/… up-regulated in the Lef1-null chondrocytes and previously …

… the chondrocyte receives and integrates into gene expression … Of the four family members
(TCF1, TCF3, TCF4, and LEF1), … evidence that chondrocyte hypertrophy is regulated by many …

… and activation of the NF-kappaB pathway by increasing the … the p65 protein from the cytoplasm
to the nucleus in chondrocytes [… The relative β-catenin mRNA expression in the OA group (…

… and functions as a transcription factor to regulate the target gene expression. However, for
the … In human chondrocytes, Wnt-3A stimulation induces the interaction of β-catenin with p65 …

… (c) Fold-change in relative gene expression of chondrogenic, … , specifically TCF4, TCF7 and
LEF1, was assessed using qRT-… -regulated target [36], promotes chondrocyte hypertrophy …

… C The mRNA expressions of chondrogenic markers including Acan, Col2a1, and Sox9 among
… We found that the expressions of Axin2, Lef-1, and Tcf-7 were decreased in Gem-Kd cells …

… The net negative charge carried by proteoglycans governs the … expression of microRNA
(miRNA) in endplate cartilage cells. The co-expression network analysis of miRNA and mRNA …

… -induced gene expression in human chondrocytes and examined TNKS-1/2 expression in
… Our data also suggested that mechanical stimulation up-regulated the expression of TNKS-1…

… chondrocytes after IL-1β stimulation. We further investigated the role of SHP2 in OA by regulating
SHP2 expression … by decreased levels of target genes such as Axin2, LEF1, and TCF4. …